Ditzy dames and best friends Dee Twiddle (Pamela Anderson) and Dawn St. Dom (Denise Richards) find themselves in the wrong place at the wrong time and witness a mob hit. Due to a series of amusing coincidences, two mafia men confuse them for a couple of world-best female assassins.

After taking the information back to their boss, the mobsters decide that the duo might be perfect for their next hit and offer the girls an absurd amount of money to complete the job. Their task will be to take out the head of the rival Chinese mafia, Mr. Wong (Byron Mann).

With the money involved, and greatly misunderstanding the meaning of 'take out', the two blondes happily accept, but soon find themselves in way over their heads as they go on a wild road adventure, simultaneously having to dodge federal agents and real mobster hit men.