On the heels of 2005's blockbuster "The 40-Year-Old Virgin," writer/director Judd Apatow again mines hilarity from the relatably human in a comedy about a one-night stand with unexpected consequences: "Knocked Up." Katherine Heigl ("Grey's Anatomy," "Roswell") joins Virgin alums Seth Rogen, Paul Rudd and Leslie Mann for a comic look about the best thing that will ever ruin your best-laid plans: parenthood. Allison Scott (Heigl) is an up-and-coming entertainment journalist whose 24-year-old life is on the fast track. more