A love story at its core, "The Yellow Handkerchief" is about three strangers of two generations bound by loneliness who reach out to one another. After embarking on a road trip through post Katrina Louisiana, their relationships forge and change in a myriad of ways, leading to the possibility of second chances.

Brett Hanson (William Hurt) dealing with a painful past, crosses paths with a lonely and troubled teenager Martine (Kristen Stewart) and her new 'ride' Gordy (Eddie Redmayne). The trio head out together, each motivated by reasons of their own.

Martine yearns to escape her family, Gordy hopes to get closer to Martine and Brett must decide whether he wants to return to the uncertainty of the life and the woman he left behind, his ex-wife May (Maria Bello). A deeply humanistic and emotionally rich film.